Tg(tetO-NEFL)173.2Jpj
Transgene Detail

Summary

• Symbol: Tg(tetO-NEFL)173.2Jpj
• Name: transgene insertion 173.2, Jean-Pierre Julien
• MGI ID: MGI:4819012
• Synonyms: Tg(hNF-L^P22S)
• Transgene: Tg(tetO-NEFL)173.2Jpj Location: unknown
• Alliance: Tg(tetO-NEFL)173.2Jpj page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-NEFL)173.2Jpj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NEFL (4747)

  Nefl	(MGI:97313)

• Mutation details: The tetracycline responsive element (TRE), minimal CMV promoter fused to the tetracycline operator, drives conditional expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of serine for proline at position 22 (P22S). Three lines were established (173.2, 173.3, and 176). (J:160704)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160704 Dequen F, et al., Reversal of neuropathy phenotypes in conditional mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2010 Jul 1;19(13):2616-29
• All: 1 reference(s)