Cd40lg^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cd40lg^m1Btlr
• Name: CD40 ligand; mutation 1, Bruce Beutler
• MGI ID: MGI:4819117
• Synonyms: walla
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation has been identified as a T to C transition at nucleotide position 673 of the transcript (NM_011616.2 from NCBI Build 37.1), in the last of the gene's 5 exons. It is predicted to result in replacement of serine by proline at amino acid position 221 of the protein, in the tumor necrosis factor (TNF)-like extracellular region. (J:162147)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 17 strains or lines available

References

• Original: J:162147 Arnold CN, et al., Record for walla, updated 26 July 2010. Accessed 27 July 2010. MGI Direct Data Submission. 2010
• All: 2 reference(s)