Zfp36l1^tm1.1Tnr
Targeted Allele Detail

Summary

• Symbol: Zfp36l1^tm1.1Tnr
• Name: zinc finger protein 36, C3H type-like 1; targeted mutation 1.1, Martin Turner
• MGI ID: MGI:4819154
• Synonyms: Zfp36l1^fl, Zfp36l1^tm1.1Trn
• Gene: Zfp36l1 Location: Chr12:80154534-80159787 bp, - strand Genetic Position: Chr12, 36.46 cM
• Alliance: Zfp36l1^tm1.1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2. The Neo cassette was removed from the germline by Flpe mediated recombination. (J:162388)

Disease models

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36l1 Mutation: 10 strains or lines available

References

• Original: J:162388 Hodson DJ, et al., Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol. 2010 Aug;11(8):717-24
• All: 10 reference(s)