Tg(STIL-TAL1)A5(3)Alpa
Transgene Detail

Summary

• Symbol: Tg(STIL-TAL1)A5(3)Alpa
• Name: transgene insertion A5(3), Peter Alpan
• MGI ID: MGI:4819165
• Synonyms: pSIL/TSCL
• Transgene: Tg(STIL-TAL1)A5(3)Alpa Location: unknown
• Alliance: Tg(STIL-TAL1)A5(3)Alpa page

Transgene origin

• Strain of Origin: (C57BL/10Ros x C3H/HeRos)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(STIL-TAL1)A5(3)Alpa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TAL1 (6886)

  Tal1	(MGI:98480)

• Mutation details: The transgene contains a fusion of the human promoter and exon 1 to the human cDNA spanning encoding amino acids 176 through 331 of TAL1. This original fusion was isolated from cell line CEM and subsequently truncated. Founders A5(1), A5(2), A5(3) and A5(4) were generated. (J:40868)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:40868 Aplan PD, et al., An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 1997 May 1;16(9):2408-19
• All: 6 reference(s)