Tg(Thy1-BACE1)54/4Ppa
Transgene Detail

Summary

• Symbol: Tg(Thy1-BACE1)54/4Ppa
• Name: transgene insertion 54/4, Paolo Paganetti
• MGI ID: MGI:4819402
• Synonyms: BACE54
• Transgene: Tg(Thy1-BACE1)54/4Ppa Location: unknown
• Alliance: Tg(Thy1-BACE1)54/4Ppa page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-BACE1)54/4Ppa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BACE1 (23621)

  Bace1

  (MGI:1346542)

• Mutation details: A human BACE1 cDNA was placed under the control of the murine Thy-1 minigene. High levels of huBACE were observed in all analysed animals of the BACE54/4 line. (J:75039)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75039 Bodendorf U, et al., Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid. J Neurochem. 2002 Mar;80(5):799-806
• All: 2 reference(s)