Tg(Lck-cre)#Nik
Transgene Detail

Summary

• Symbol: Tg(Lck-cre)#Nik
• Name: transgene insertion, Nigel Killeen
• MGI ID: MGI:4819511
• Synonyms: Dlck-cre, dLck-iCre
• Transgene: Tg(Lck-cre)#Nik Location: unknown
• Alliance: Tg(Lck-cre)#Nik page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lck-cre)#Nik expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lck

• Mutation details: This transgene expresses cre recombinase under the control of the distal Lck promoter. This transgene is expressed in T cells primarily after Tcra locus rearrangement and the cells have reached the TCR^hi stage of development. Lines 3778, 3779, and 3385. The symbol # denotes that no line number was specified or lines were pooled. (J:73479, J:99042)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (species not specified) Summary of all recombinase alleles driven by Lck.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:161995 Lee K, et al., Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010 Jun 25;32(6):743-53
• All: 36 reference(s)