Eef2k^tm1Agry
Targeted Allele Detail

Summary

• Symbol: Eef2k^tm1Agry
• Name: eukaryotic elongation factor-2 kinase; targeted mutation 1, Alexey G Ryazanov
• MGI ID: MGI:4819586
• Gene: Eef2k Location: Chr7:120442080-120506441 bp, + strand Genetic Position: Chr7, 64.95 cM, cytoband F3
• Alliance: Eef2k^tm1Agry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162129
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 and most of exon 8 were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:208406)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef2k Mutation: 43 strains or lines available

References

• Original: J:162129 Khan AA, et al., Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol. 2010 Jul;177(1):481-92
• All: 15 reference(s)