Trp53^tm1.1Dgj
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Dgj
• Name: transformation related protein 53; targeted mutation 1.1, David G Johnson
• MGI ID: MGI:4819616
• Synonyms: p53^P, Trp53^R72P
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Dgj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162466
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 4 was replaced with a modified human exon 4 in which nucleotide substitution created the proline variant of the p.R72P polymorphism (SNP rs1042522). A loxP site flanked neomycin resistance gene cassette inserted upstream of exon 2 was removed by Cre-mediated recombination. (J:162466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:162466 Zhu F, et al., Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010 Jul 15;70(14):5851-9
• All: 2 reference(s)