Tg(TRP53*R72P)7Dgj
Transgene Detail

Summary

• Symbol: Tg(TRP53*R72P)7Dgj
• Name: transgene insertion 7, David G Johnson
• MGI ID: MGI:4819620
• Synonyms: p53P #7
• Transgene: Tg(TRP53*R72P)7Dgj Location: unknown
• Alliance: Tg(TRP53*R72P)7Dgj page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Single point mutation
• Tg(TRP53*R72P)7Dgj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TP53 (7157)

  Trp53

  (MGI:98834)

  Transgene codes for a protein with an arginine to proline mutation.

• Mutation details: The transgene contains human BAC 66H22 in which TRP53 was mutated to code a proline at position 72 instead of arginine. Both amino acids are polymorphic variants observed in humans. Line 7 was generated. (J:162466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:162466 Zhu F, et al., Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010 Jul 15;70(14):5851-9
• All: 3 reference(s)