Tg(TRP53*R72P)7Dgj
Transgene Detail

Summary

• Symbol: Tg(TRP53*R72P)7Dgj
• Name: transgene insertion 7, David G Johnson
• MGI ID: MGI:4819620
• Synonyms: p53P #7
• Transgene: Tg(TRP53*R72P)7Dgj Location: unknown
• Alliance: Tg(TRP53*R72P)7Dgj page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Single point mutation
• Tg(TRP53*R72P)7Dgj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TP53 (7157)

  Trp53

  (MGI:98834)

  Transgene codes for a protein with an arginine to proline mutation.

• Mutation details: The transgene contains human BAC 66H22 in which TRP53 was mutated to code a proline at position 72 instead of arginine. Both amino acids are polymorphic variants observed in humans. Line 7 was generated. (J:162466)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(TRP53*R72P)7Dgj/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * FVB

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
cellular	√
decreased cellular sensitivity to ultraviolet irradiation	√
neoplasm	√
decreased lymphoma incidence	√
increased hemangiosarcoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:162466 Zhu F, et al., Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010 Jul 15;70(14):5851-9
• All: 3 reference(s)