Vmn2r116^tm1.1Ktou
Targeted Allele Detail

Summary

• Symbol: Vmn2r116^tm1.1Ktou
• Name: vomeronasal 2, receptor 116; targeted mutation 1.1, Kazushige Touhara
• MGI ID: MGI:4819730
• Gene: Vmn2r116 Location: Chr17:23603777-23620838 bp, + strand Genetic Position: Chr17, 11.56 cM
• Alliance: Vmn2r116^tm1.1Ktou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 6, which encodes the transmembrane domain, was replaced with an IRES-GAP43-Venus and a self-excising neo cassette. Cre mediated recombination removed the neo cassette. The absence of protein expression was confirmed by immunohistochemitry of vomeronasal organ sections. (J:162636)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vmn2r116 Mutation: 49 strains or lines available

References

• Original: J:162636 Haga S, et al., The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor. Nature. 2010 Jul 1;466(7302):118-22
• All: 3 reference(s)