Atxn1l^tm1.1Hzo
Targeted Allele Detail

Summary

• Symbol: Atxn1l^tm1.1Hzo
• Name: ataxin 1-like; targeted mutation 1.1, Huda Y Zoghbi
• MGI ID: MGI:4819750
• Synonyms: Atxn1l^dp
• Gene: Atxn1l Location: Chr8:110453083-110464371 bp, - strand Genetic Position: Chr8, 57.22 cM
• Alliance: Atxn1l^tm1.1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119643
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Duplication, Insertion
• Atxn1l^tm1.1Hzo involves 1 genes/genome features (Atxn1l) View all
• Mutation details: Homologous recombination duplicated the gene. Cre mediated recombination removed the floxed neo cassette leaving a portion of the gene floxed. Western blot analysis confirmed increased protein expression. (J:119643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atxn1l Mutation: 24 strains or lines available

References

• Original: J:119643 Bowman AB, et al., Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Nat Genet. 2007 Mar;39(3):373-379
• All: 3 reference(s)