Il1rn^tm1.1Cga
Targeted Allele Detail

Summary

• Symbol: Il1rn^tm1.1Cga
• Name: interleukin 1 receptor antagonist; targeted mutation 1.1, Cem Gabay
• MGI ID: MGI:4819784
• Synonyms: IL-1Ra^flx
• Gene: Il1rn Location: Chr2:24226872-24241503 bp, + strand Genetic Position: Chr2, 16.36 cM
• Alliance: Il1rn^tm1.1Cga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162760
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked with loxP sites. Flp mediated recombination removed the FRT flanked neo cassette upstream of exon 2. (J:162760)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rn Mutation: 23 strains or lines available

References

• Original: J:162760 Lamacchia C, et al., Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist. Arthritis Rheum. 2010 Feb;62(2):452-62
• All: 4 reference(s)