Ptprc^a
Allele Detail

Summary

• Symbol: Ptprc^a
• Name: protein tyrosine phosphatase receptor type C; a variant
• MGI ID: MGI:4819849
• Synonyms: CD45.1, Ly5^a, Ptprc^SJL
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^a page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable
• Mutation: Nucleotide substitutions
• Mutation details: Ptprc^a is found in strains SJL/J, STS/A, and DA. Ptprc^b is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, J:8603). Twelve nucleotide differences between the a and b alleles have been identified. These base substitutions correspond to five amino-acid changes within the extracellular domain of the encoded protein. These amino-acid differences are clustered in a region that also contains the greatest divergence between mouse and rat sequences (J:22485).
  
  Note that the allele designations originally described were reversed in 1987 (J:8603); all publications prior to 1987 show SJL/J, STS/A, and DA as having the b allele and the C57BL/6J group as having the a allele (J:22341). (J:8080, J:12548, J:22485)

Tumor Data

List all tumor models in MMHCdb carrying Ptprc^a

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 51 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
• All: 197 reference(s)