Fgf14^{Tg(tetO-MAPT*P301L)4510Kha}
Transgenic Allele Detail

Summary

• Symbol: Fgf14^{Tg(tetO-MAPT*P301L)4510Kha}
• Name: fibroblast growth factor 14; transgene insertion 4510, Karen Hsiao Ashe
• MGI ID: MGI:4819866
• Synonyms: rTg4510, rTgP301L, Tg4510, Tg(tauP301L)4510, Tg(tetO-MAPT*P301L)4510Kha, Tg(tetO-MAPT*P301L)#Kha, Tg(tetO-TauP301L)4510
• Gene: Fgf14 Location: Chr14:124215319-124914539 bp, - strand Genetic Position: Chr14, 66.18 cM
• Alliance: Fgf14^{Tg(tetO-MAPT*P301L)4510Kha} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Null/knockout)
• Inducer: doxycycline/tetracycline
• Mutations: Insertion, Intragenic deletion
• Fgf14^{Tg(tetO-MAPT*P301L)4510Kha} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Fgf14^{Tg(tetO-MAPT*P301L)4510Kha} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details: The human four-repeat tau gene lacking the amino-terminal sequences (4R0N) containing the frontotemporal dementia-associated P301L mutation sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and inserted into the context of the mouse prion protein gene (prnp) exons 2-3 transcribed but untranslated sequences. When mice are crossed with a line expressing a tTA transgene, Tg(Camk2a-tTA)1Mmay, these mice show the doxycycline sensitivity for transgene suppression. At least two bitransgenic lines were established that can be suppressed with doxycycline. One bitransgenic mouse strain expressing approximately 13 units of tauP301L transgene was named rTg(tau P301L)4510 and was analyzed further. Line 4510 inserted into the gene at 124457842-124702169 (Build GRCm38/mm10) resulting in a 244,327 bp deletion. (J:99626)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fgf14 Mutation: 40 strains or lines available

References

• Original: J:99626 Santacruz K, et al., Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005 Jul 15;309(5733):476-81
• All: 145 reference(s)