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ComtB2i
Spontaneous Allele Detail
Summary
Symbol: ComtB2i
Name: catechol-O-methyltransferase; B2 insertion
MGI ID: MGI:4819952
Synonyms: +SINE
Gene: Comt  Location: Chr16:18225636-18245602 bp, - strand  Genetic Position: Chr16, 11.4 cM
Alliance: ComtB2i page
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsThis mutation is an insertion of a B2 short interspersed element (SINE) in the 3' untranslated region (UTR) of the gene. The transcript from the mutant allele terminates at the 3' end of the SINE, with the consequence that the mutant mRNA is ~460 bp shorter than the reference sequence (NM 001111062). Higher mRNA levels are present in the nucleus accumbens and striatum of C57BL/6J (Comt1B2i/Comt1B2i) than of DBA/2J (Comt+/Comt+) mice. The hippocampal COMT1 specific activity of male C57BL/6J mice is ~1.7-fold that of DBA/2J males. (J:162759)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Comt Mutation:  24 strains or lines available
Notes
Comt1B2i inbred mouse strains: 129S1/SvImJ, 129T2/SvEmsJ, 129X1/SvJ, A/J, AKR/J, BALB/cByJ, BALB/cJ, BTBR T+ tf, SM/J, C57BL/10J, C57BL/6J, MRL/MpJ, NOD/ShiLtJ, NON/ShiLtJ, BUB/BnJ, CE/J, LG/J, PL/J
Comt+ inbred mouse strains: BDP/J, C3H/HEJ, C3HeB/FeJ, C57BR/cdJ, C57L/J, C58/J, CAST/Ei, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, IS/CamEi, IS/CamRk, KK/HlJ, LP/J, MOLF/Ei, MOLG/Dn, NZB/BlNJ, NZW/LacJ, P/J, PERA/Rk, PERC/Ei, PWD, RIIIS/DmMob, RIIIS/J, SF/CamEi, SJL/J, SKIVE/Ei, SPRET/Ei, ST/bJ, SWR/J
References
Original:  J:162759 Kember RL, et al., A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes Brain Behav. 2010 Nov;9(8):925-32
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory