Comt^B2i
Spontaneous Allele Detail

Summary

• Symbol: Comt^B2i
• Name: catechol-O-methyltransferase; B2 insertion
• MGI ID: MGI:4819952
• Synonyms: +SINE
• Gene: Comt Location: Chr16:18225636-18245602 bp, - strand Genetic Position: Chr16, 11.4 cM
• Alliance: Comt^B2i page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: This mutation is an insertion of a B2 short interspersed element (SINE) in the 3' untranslated region (UTR) of the gene. The transcript from the mutant allele terminates at the 3' end of the SINE, with the consequence that the mutant mRNA is ~460 bp shorter than the reference sequence (NM 001111062). Higher mRNA levels are present in the nucleus accumbens and striatum of C57BL/6J (Comt1^B2i/Comt1^B2i) than of DBA/2J (Comt⁺/Comt⁺) mice. The hippocampal COMT1 specific activity of male C57BL/6J mice is ~1.7-fold that of DBA/2J males. (J:162759)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Comt Mutation: 24 strains or lines available

Notes

Comt1^B2i inbred mouse strains: 129S1/SvImJ, 129T2/SvEmsJ, 129X1/SvJ, A/J, AKR/J, BALB/cByJ, BALB/cJ, BTBR T⁺ tf, SM/J, C57BL/10J, C57BL/6J, MRL/MpJ, NOD/ShiLtJ, NON/ShiLtJ, BUB/BnJ, CE/J, LG/J, PL/J
Comt⁺ inbred mouse strains: BDP/J, C3H/HEJ, C3HeB/FeJ, C57BR/cdJ, C57L/J, C58/J, CAST/Ei, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, IS/CamEi, IS/CamRk, KK/HlJ, LP/J, MOLF/Ei, MOLG/Dn, NZB/BlNJ, NZW/LacJ, P/J, PERA/Rk, PERC/Ei, PWD, RIIIS/DmMob, RIIIS/J, SF/CamEi, SJL/J, SKIVE/Ei, SPRET/Ei, ST/bJ, SWR/J

References

• Original: J:162759 Kember RL, et al., A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes Brain Behav. 2010 Nov;9(8):925-32
• All: 6 reference(s)