Bmal1^tm2Bra
Targeted Allele Detail

Summary

• Symbol: Bmal1^tm2Bra
• Name: basic helix-loop-helix ARNT like 1; targeted mutation 1, Chris Bradfield
• MGI ID: MGI:4819968
• Synonyms: Bmal1^fx
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^tm2Bra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155089
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:162641, J:190442, J:216930)

Generation of the Bmal1^tm2Bra allele

Disease models

Expression

In Mice Carrying this Mutation:	6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 139 strains or lines available

References

• Original: J:155089 Westgate EJ, et al., Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation. 2008 Apr 22;117(16):2087-95
• All: 21 reference(s)