Sox10^{tm7.1(Sox10)Weg}
Targeted Allele Detail

Summary

• Symbol: Sox10^{tm7.1(Sox10)Weg}
• Name: SRY (sex determining region Y)-box 10; targeted mutation 7.1, Michael Wegner
• MGI ID: MGI:4820417
• Synonyms: Sox10^fl
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^{tm7.1(Sox10)Weg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162692
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. The coding region was replaced with a cDNA of the rat homolog, a floxed and FRT flanked neo cassette, and an IRES-EGFP-pA cassette. Flp mediated recombination removed the neo cassette leaving the the rat cDNA floxed and the reporter cassette intact. (J:162692)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:162692 Finzsch M, et al., Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010 May 17;189(4):701-12
• All: 21 reference(s)