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Tg(Myh6-MYL2*R58Q)#Dsc
Transgene Detail
Summary
Symbol: Tg(Myh6-MYL2*R58Q)#Dsc
Name: transgene insertion, Danuta Szczesna-Cordary
MGI ID: MGI:4820518
Synonyms: Tg-R58Q
Transgene: Tg(Myh6-MYL2*R58Q)#Dsc  Location: unknown  
Alliance: Tg(Myh6-MYL2*R58Q)#Dsc page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-MYL2*R58Q)#Dsc expresses 1 gene
 
Mutation detailsThe human ventricular myosin regulatory light chain with with an arginine to glutamine substitution at amino acid 58 (R58Q, a familial hypertrophic cardiomyopathy-linked mutation) is under the control of about 5.5 kb of the mouse alpha-myosin heavy chain promoter which includes the first two exons and part of the third. Two lines (9 and 8) were generated, however the pound symbol (#) is used when line is not specified or lines are pooled. (J:144685)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144685 Wang Y, et al., Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations. J Mol Biol. 2006 Aug 11;361(2):286-99
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory