Tg(Myh6-MYL2*R58Q)#Dsc
Transgene Detail
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Symbol: |
Tg(Myh6-MYL2*R58Q)#Dsc |
Name: |
transgene insertion, Danuta Szczesna-Cordary |
MGI ID: |
MGI:4820518 |
Synonyms: |
Tg-R58Q |
Transgene: |
Tg(Myh6-MYL2*R58Q)#Dsc Location: unknown
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Alliance: |
Tg(Myh6-MYL2*R58Q)#Dsc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-MYL2*R58Q)#Dsc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYL2 (4633) |
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Mutation details: The human ventricular myosin regulatory light chain with with an arginine to glutamine substitution at amino acid 58 (R58Q, a familial hypertrophic cardiomyopathy-linked mutation) is under the control of about 5.5 kb of the mouse alpha-myosin heavy chain promoter which includes the first two exons and part of the third. Two lines (9 and 8) were generated, however the pound symbol (#) is used when line is not specified or lines are pooled.
(J:144685)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:144685 Wang Y, et al., Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations. J Mol Biol. 2006 Aug 11;361(2):286-99 |
All: |
7 reference(s) |
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