Ptk2^tm2.1Guan
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm2.1Guan
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 2.1, Jun-Lin Guan
• MGI ID: MGI:4820570
• Synonyms: FAK^KD
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm2.1Guan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162690
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A lysine to arginine substitution at residue 454 (K454R) was introduced into exon 16 and a Neo cassette flanked by loxP sites was inserted into the upstream intron via homologous recombination. The Neo cassette was removed by Cre mediated recombination. (J:162690)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:162690 Zhao X, et al., Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol. 2010 Jun 14;189(6):955-65
• All: 4 reference(s)