Mtor^tm1Koz
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1Koz
• Name: mechanistic target of rapamycin kinase; targeted mutation 1, Sara C Kozma
• MGI ID: MGI:4820591
• Synonyms: mTOR^lx, mTOR^neo
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1Koz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced upstream of the mTOR promoter region and a neo cassette flanked by two loxP sites was inserted in the intron preceding exon 6. (J:94133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:94133 Gangloff YG, et al., Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004 Nov;24(21):9508-16
• All: 19 reference(s)