Psmg1^tm1.1Smta
Targeted Allele Detail

Summary

• Symbol: Psmg1^tm1.1Smta
• Name: proteasome (prosome, macropain) assembly chaperone 1; targeted mutation 1.1, Shigeo Murata
• MGI ID: MGI:4820728
• Synonyms: Psmg1^F
• Gene: Psmg1 Location: Chr16:95781133-95792160 bp, - strand Genetic Position: Chr16, 56.76 cM
• Alliance: Psmg1^tm1.1Smta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162790
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:162790)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psmg1 Mutation: 20 strains or lines available

References

• Original: J:162790 Sasaki K, et al., PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol. 2010 Aug;30(15):3864-74
• All: 1 reference(s)