Psmg1^tm1.2Smta
Targeted Allele Detail

Summary

• Symbol: Psmg1^tm1.2Smta
• Name: proteasome (prosome, macropain) assembly chaperone 1; targeted mutation 1.2, Shigeo Murata
• MGI ID: MGI:4820730
• Gene: Psmg1 Location: Chr16:95781133-95792160 bp, - strand Genetic Position: Chr16, 56.76 cM
• Alliance: Psmg1^tm1.2Smta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162790
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 2. The absence of protein expression was confirmed by immunohistochemistry on E6 embryos in utero. (J:162790)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmg1 Mutation: 20 strains or lines available

References

• Original: J:162790 Sasaki K, et al., PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol. 2010 Aug;30(15):3864-74
• All: 1 reference(s)