Fzr1^{tm1(Fzr1)Shku}
Targeted Allele Detail

Summary

• Symbol: Fzr1^{tm1(Fzr1)Shku}
• Name: fizzy and cell division cycle 20 related 1; targeted mutation 1, Shinji Kuninaka
• MGI ID: MGI:4820748
• Synonyms: Cdh1^KI
• Gene: Fzr1 Location: Chr10:81202713-81214204 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Fzr1^{tm1(Fzr1)Shku} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162785
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The beta-geo cassette contained within Fzr1^Gt(3003)Tgen was replaced with the mouse cDNA and an FRT flanked puro cassette. During the replacement the lox71 site was fused to the lox66 site while the additional loxP and lox2272 sites remain intact. (J:162785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzr1 Mutation: 43 strains or lines available

References

• Original: J:162785 Naoe H, et al., The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol. 2010 Aug;30(16):3994-4005
• All: 3 reference(s)