Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:4820800
• Synonyms: Gt(Rosa)26Sor^tm1/Sox2/blh, Rosa26R^{Sox2-IRES-GFP}, ROSA26-SOX2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: A CAG promoter drives expression of the mouse cDNA and IRES-EGFP preceded by a floxed neo-STOP cassette. Cre mediated recombination is necessary to achieve expression of the mouse cDNA and reporter cassette. (J:161806)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:161806 Lu Y, et al., Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One. 2010;5(6):e11022
• All: 12 reference(s)