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Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:4820800
Synonyms: Gt(Rosa)26Sortm1/Sox2/blh, Rosa26RSox2-IRES-GFP, ROSA26-SOX2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161806
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh expresses 1 gene
 
Mutation detailsA CAG promoter drives expression of the mouse cDNA and IRES-EGFP preceded by a floxed neo-STOP cassette. Cre mediated recombination is necessary to achieve expression of the mouse cDNA and reporter cassette. (J:161806)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:161806 Lu Y, et al., Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One. 2010;5(6):e11022
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory