Mtor^tm1.1Clyn
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.1Clyn
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.1, Christopher Lynch
• MGI ID: MGI:4820819
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.1Clyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed the neo cassette, exon 49, and the modified exon 50. Reduced protein expression was confirmed by western blot analysis on heart and liver extracts from heterozygotes. (J:162945)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:162945 Lang CH, et al., Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1283-94
• All: 7 reference(s)