Traf3ip2^adjm
Spontaneous Allele Detail

Summary

• Symbol: Traf3ip2^adjm
• Name: TRAF3 interacting protein 2; atopic dermatitis from Japanese mice
• MGI ID: MGI:4820827
• Gene: Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
• Alliance: Traf3ip2^adjm page

Mutation origin

• Strain of Origin: KOR

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: A spontaneous mutation resulted in a C to T transition in the second exon. The transition results in a C- terminal truncation by changing amino acid 214 from glutamine (CAG) to a stop codon (TAG). RT-PCR showed reduced transcript level and western blots of protein extracts from spleens showed no specific Ab labeling in the positions expected for TRAF3IP2.
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Traf3ip2 Mutation: 41 strains or lines available

References

• Original: J:162859 Matsushima Y, et al., An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene. J Immunol. 2010 Aug 15;185(4):2340-9
• All: 1 reference(s)