Gck^m1Rge
Chemically induced Allele Detail

Summary

• Symbol: Gck^m1Rge
• Name: glucokinase; ENU mutation 1, University of Munich
• MGI ID: MGI:4820836
• Synonyms: GLS001, Munich Gck^M210R
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^m1Rge page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G-to-T transition at position 629 in exon 6 (NCBI GenBank accession no. NM_010292). This point mutation results in an amino acid substitution of methionine with arginine at position 210 (p.M210R). (J:162903)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:162903 van Burck L, et al., Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23
• All: 2 reference(s)