Gt(ROSA)26Sor^{tm2(Foxo1)Jnk}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Foxo1)Jnk}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jun Nakae
• MGI ID: MGI:4820847
• Synonyms: R26^{floxneoCNFoxO1}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Foxo1)Jnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Foxo1)Jnk} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Foxo1 (MGI:1890077)

• Mutation details: An expression cassette containing a floxed neo-STOP cassette followed by a constitutively nuclear (CN), FLAG-tagged mouse cDNA (alanine substitutions T24A/S253A/S316A) was inserted into the locus. Cre mediated expression is required to achieve expression of the truncated cDNA. (J:162892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:162892 Iskandar K, et al., PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E787-98
• All: 3 reference(s)