Tg(SOD1*G93A)G20Gur
Transgene Detail

Summary

• Symbol: Tg(SOD1*G93A)G20Gur
• Name: transgene insertion G20, Mark E Gurney
• MGI ID: MGI:4820848
• Synonyms: G20
• Transgene: Tg(SOD1*G93A)G20Gur Location: unknown
• Alliance: Tg(SOD1*G93A)G20Gur page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene construct consists of a human SOD1 gene carrying a glycine to alanine substitution at position 93 (G93A). The G93A mutation does not alter the activity of the protein. Northern blot and Western blot confirmed the expression of the human transgene in transgenic animals. (J:32665)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
• All: 2 reference(s)