Tg(Dbh-cre/ERT2)198.1Hroh
Transgene Detail

Summary

• Symbol: Tg(Dbh-cre/ERT2)198.1Hroh
• Name: transgene insertion 198.1, Hermann Rohrer
• MGI ID: MGI:4821735
• Synonyms: DBH^CreERT2, DBH-CT198.1
• Transgene: Tg(Dbh-cre/ERT2)198.1Hroh Location: unknown
• Alliance: Tg(Dbh-cre/ERT2)198.1Hroh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Dbh-cre/ERT2)198.1Hroh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dbh (MGI:94864)

• Mutation details: A cre-ERT2 cassette with a polyA sequence was inserted into a BAC containing the mouse Dbh gene by homologous recombination, resulting in cre expression directed by the Dbh promoter. This construct was integrated into the C57BL/6 background. Cre induction by tamoxifen in mice crossed to a reporter line exhibited cre activity in noradrenergic cells (sympathetic ganglia, adrenal chromaffin cells, and the locus ceruleus). (J:163233, J:180731)

Generation of Tg(Dbh-cre/ERT2)198.1Hroh.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dbh (mouse) Summary of all recombinase alleles driven by Dbh. Comparative matrix view of recombinase activities Alliance mouse Dbh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:163233 Tsarovina K, et al., The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci. 2010 Aug 11;30(32):10833-43
• All: 6 reference(s)