Tpi1^a-m6Neu
Chemically induced Allele Detail

Summary

• Symbol: Tpi1^a-m6Neu
• Name: triosephosphate isomerase 1; mutation 6, Neuherberg
• MGI ID: MGI:4821798
• Gene: Tpi1 Location: Chr6:124787549-124791121 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Tpi1^a-m6Neu page

Mutation origin

• Strain of Origin: (101/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: Triethylenemelamine mutagenesis induced an A to G transition at position 149 of exon 2 (GenBank/EMBL accession number NM009415) that results in the amino acid substitution of glycine for aspartic acid at position 49 (D49G). Triosephosphate isomerase activity in the blood, lung, spleen, heart, liver, kidney, and brain is reduced in heterozygotes and homozygotes. (J:163223)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tpi1 Mutation: 24 strains or lines available

References

• Original: J:163223 Pretsch W, Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition. Genet Res. 2009 Feb;91(1):1-4
• All: 1 reference(s)