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Col4a1F247
Radiation induced Allele Detail
Summary
Symbol: Col4a1F247
Name: collagen, type IV, alpha 1; radiation induced mutation F247
MGI ID: MGI:4822166
Gene: Col4a1  Location: Chr8:11248423-11362826 bp, - strand  Genetic Position: Chr8, 5.53 cM
Alliance: Col4a1F247 page
Mutation
origin
Strain of Origin:  (102 x C3H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Single point mutation
 
Mutation detailsMale mice were exposed to 3 Gy of gamma radiation. This resulted in a G to C nucleotide substitution at position 4152 (NCBI accession # NM_009931) and a glycine to arginine substitution at amino acid residue 1341. (J:163225)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col4a1 Mutation:  78 strains or lines available
References
Original:  J:163225 Favor J, et al., Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4a1 allelic series and the identification ofthe first two Col4a2 mutant alleles. Genetics. 2007 Feb;175(2):725-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory