Aplp2^tm1.1Umu
Targeted Allele Detail

Summary

• Symbol: Aplp2^tm1.1Umu
• Name: amyloid beta precursor-like protein 2; targeted mutation 1.1, Ulrike Muller
• MGI ID: MGI:4822176
• Synonyms: Aplp2^flox, Aplp2^tm1.1Mull
• Gene: Aplp2 Location: Chr9:31060853-31123111 bp, - strand Genetic Position: Chr9, 16.66 cM, cytoband A2-B
• Alliance: Aplp2^tm1.1Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163059
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo resistance cassette was inserted 5' to exon 1 as well as an additional loxP site within intron 1 by homologous recombination. The neo cassette and exon 1 were removed by cre mediated recombination. (J:163059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplp2 Mutation: 32 strains or lines available

References

• Original: J:163059 Mallm JP, et al., Generation of conditional null alleles for APP and APLP2. Genesis. 2010 Mar;48(3):200-6
• All: 2 reference(s)