App^tm3.2Umu
Targeted Allele Detail

Summary

• Symbol: App^tm3.2Umu
• Name: amyloid beta precursor protein; targeted mutation 3.2, Ulrike Muller
• MGI ID: MGI:4822178
• Synonyms: App^tm3.2Mull
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm3.2Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163059
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo resistance cassette was inserted 5' to exon 1 as well as an additional loxP site within intron 1 by homologous recombination. The neo cassette and exon 1 were removed by cre mediated recombination. Western blot analysis revealed the absence of any detectable protein expression. (J:163059)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:163059 Mallm JP, et al., Generation of conditional null alleles for APP and APLP2. Genesis. 2010 Mar;48(3):200-6
• All: 1 reference(s)