Alkbh8^tm1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh8^tm1Klng
• Name: alkB homolog 8, tRNA methyltransferase; targeted mutation 1, Arne Klungland
• MGI ID: MGI:4822190
• Gene: Alkbh8 Location: Chr9:3335151-3391154 bp, + strand Genetic Position: Chr9, 2.02 cM, cytoband A1
• Alliance: Alkbh8^tm1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161726
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons 9-10, encoding a part of the AlkB and the methltranferase domains, respectively, were replaced with LoxP franked neo cassette by targeted recombination. (J:161726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh8 Mutation: 33 strains or lines available

References

• Original: J:161726 Songe-Moller L, et al., Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol Cell Biol. 2010 Apr;30(7):1814-27
• All: 1 reference(s)