Cacng2^tm1.1Suto
Targeted Allele Detail

Summary

• Symbol: Cacng2^tm1.1Suto
• Name: calcium channel, voltage-dependent, gamma subunit 2; targeted mutation 1.1, Susumu Tomita
• MGI ID: MGI:4822223
• Synonyms: stargazin^SD
• Gene: Cacng2 Location: Chr15:77875948-78004228 bp, - strand Genetic Position: Chr15, 36.92 cM
• Alliance: Cacng2^tm1.1Suto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was subjected to nucleotide substitutions that result in nine phosphorylatable serines being replaced with aspartic acids. A floxed neo cassette inserted into 3'UTR was removed by cre mediated recombination. These substitutions result in a phospho-mimic protein. (J:163184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacng2 Mutation: 26 strains or lines available

References

• Original: J:163184 Sumioka A, et al., TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers. Neuron. 2010 Jun 10;66(5):755-67
• All: 1 reference(s)