Sorbs3^tm1Kiok
Targeted Allele Detail

Summary

• Symbol: Sorbs3^tm1Kiok
• Name: sorbin and SH3 domain containing 3; targeted mutation 1, Noriyuki Kioka
• MGI ID: MGI:4822403
• Synonyms: vinexin^-
• Gene: Sorbs3 Location: Chr14:70417917-70449438 bp, - strand Genetic Position: Chr14, 36.27 cM
• Alliance: Sorbs3^tm1Kiok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162344
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of an intron and an exon encoding the first SH3 domain which is shared by all known vinexin variants was replaced with a neo cassette by targeted recombination. Absence of alpha and beta variants of the vinexin protein was confirmed by Western blot. (J:162344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sorbs3 Mutation: 33 strains or lines available

References

• Original: J:162344 Kioka N, et al., Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. Exp Cell Res. 2010 Jun 10;316(10):1728-38
• All: 5 reference(s)