Myof^tm1Mcn
Targeted Allele Detail

Summary

• Symbol: Myof^tm1Mcn
• Name: myoferlin; targeted mutation 1, Elizabeth McNally
• MGI ID: MGI:4822406
• Synonyms: MKO
• Gene: Myof Location: Chr19:37887484-38032025 bp, - strand Genetic Position: Chr19, 32.53 cM
• Alliance: Myof^tm1Mcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The transcription start site and exon 1 which contains the translation start site were replaced with a floxed neomycin selection cassette. Transcripts starting with exon 2 can be detected by RT-PCR but no protein can be detected immunologically. (J:163585)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myof Mutation: 101 strains or lines available

References

• Original: J:163585 Doherty KR, et al., Normal myoblast fusion requires myoferlin. Development. 2005 Dec;132(24):5565-75
• All: 3 reference(s)