Capn8^tm1Hiso
Targeted Allele Detail

Summary

• Symbol: Capn8^tm1Hiso
• Name: calpain 8; targeted mutation 1, Hiroyuki Sorimachi
• MGI ID: MGI:4822421
• Gene: Capn8 Location: Chr1:182392572-182459917 bp, + strand Genetic Position: Chr1, 85.37 cM, cytoband H4
• Alliance: Capn8^tm1Hiso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163312
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on gastric mucosa. (J:163312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Capn8 Mutation: 40 strains or lines available

References

• Original: J:163312 Hata S, et al., Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet. 2010;6(7):e1001040
• All: 2 reference(s)