Crygc^M1Sbao
Spontaneous Allele Detail

Summary

• Symbol: Crygc^M1Sbao
• Name: crystallin, gamma C; mutation 1, Shimin Bao
• MGI ID: MGI:4822430
• Gene: Crygc Location: Chr1:65110684-65112691 bp, - strand Genetic Position: Chr1, 32.81 cM
• Alliance: Crygc^M1Sbao page

Nuclear cataracts in Crygc^M1Sbao/Crygc^M1Sbao and Crygc^M1Sbao/Crygc⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: A spontaneous mutation arose in the F1 hybrids of BALB/cJ and ICR mice in which a single base pair was deleted from exon 3. This deletion results in novel amino acids 70 to 76 and a premature stop codon at amino acid 76. Sequence homology analysis confirmed that the mutation arose in the ICR strain. (J:163241)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crygc Mutation: 13 strains or lines available

References

• Original: J:163241 Zhao L, et al., A 1-bp deletion in the gammaC-crystallin leads to dominant cataracts in mice. Mamm Genome. 2010 Aug;21(7-8):361-9
• All: 2 reference(s)