Nfkbib^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Nfkbib^tm1Bal
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; targeted mutation 1, David Baltimore
• MGI ID: MGI:4822433
• Gene: Nfkbib Location: Chr7:28457676-28466069 bp, - strand Genetic Position: Chr7, 16.91 cM, cytoband A3-B3
• Alliance: Nfkbib^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163302
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot on extracts from E12.5-derived mouse embryonic fibroblasts. (J:163302)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbib Mutation: 14 strains or lines available

References

• Original: J:163302 Rao P, et al., IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature. 2010 Aug 26;466(7310):1115-9
• All: 4 reference(s)