Itgax^{tm1.1(HBEGF)Ktak}
Targeted Allele Detail

Summary

• Symbol: Itgax^{tm1.1(HBEGF)Ktak}
• Name: integrin alpha X; targeted mutation 1.1, Kiyoshi Takeda
• MGI ID: MGI:4822468
• Synonyms: iDTRdelta
• Gene: Itgax Location: Chr7:127728719-127749829 bp, + strand Genetic Position: Chr7, 69.98 cM
• Alliance: Itgax^{tm1.1(HBEGF)Ktak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162397
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Itgax^{tm1.1(HBEGF)Ktak} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  monkey	HBEGF

• Mutation details: Cre mediated recombination removed the double poly-adenylation sequences, FRT flanked neo cassette, and STOP cassette allowing for expression of the simian diphtheria toxin receptor cDNA. In vitro and in vivo treatment with diphtheria toxin depletes cells expression the allele. (J:162397)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgax Mutation: 76 strains or lines available

References

• Original: J:162397 Okuyama M, et al., A novel in vivo inducible dendritic cell ablation model in mice. Biochem Biophys Res Commun. 2010 Jul 2;397(3):559-63
• All: 1 reference(s)