Adam17^tm1Srj
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1Srj
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Stefan Rose-John
• MGI ID: MGI:4822481
• Synonyms: ADAM17^exneo
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1Srj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. An artificial exon (11a) was created in intron 11 by inserting a cryptic splice donor site upstream of an existing cryptic acceptor site in intron 11. If spliced in, exon 11a creates a truncated CDS owing to an in-frame stop codon at the 5' end. A loxP site was inserted at the 3' end of exon 11a. (J:163380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 64 strains or lines available

References

• Original: J:163380 Chalaris A, et al., Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 2010 Aug 2;207(8):1617-24
• All: 1 reference(s)