Mir144/Mir451a^tm1.1Mjwe
Targeted Allele Detail

Summary

• Symbol: Mir144/Mir451a^tm1.1Mjwe
• Name: microRNA 144; targeted mutation 1.1, Mitchell J Weiss
• MGI ID: MGI:4829379
• Synonyms: mir-451-KO
• Gene: Mir144 Location: Chr11:77963831-77963896 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Mir144/Mir451a^tm1.1Mjwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163250
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Pre-Mir144 and pre-Mir451 regions were replaced with a floxed neo cassette by homologous recombination. The selection cassette was removed by cre mediated recombination. (J:163250)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Mir144/Mir451a^tm1.1Mjwe/Mir144/Mir451a^tm1.1Mjwe	Not Specified

Phenotypes:

Affected Systems	hm1
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cellular	√
increased cellular sensitivity to hydrogen peroxide	√
growth/size/body	√
increased spleen weight	√
spleen hyperplasia	√
hematopoietic system	√
increased spleen weight	√
spleen hyperplasia	√
anemia	√
decreased hemoglobin content	√
decreased mean corpuscular hemoglobin	√
decreased mean corpuscular volume	√
increased red blood cell distribution width	√
increased number of Heinz bodies	√
polychromatophilia	√
reticulocytosis	√
homeostasis/metabolism	√
decreased catalase activity	√
abnormal physiological response to xenobiotic	√
immune system	√
increased spleen weight	√
spleen hyperplasia	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir144 Mutation: 3 strains or lines available

References

• Original: J:163250 Yu D, et al., miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev. 2010 Aug 1;24(15):1620-33
• All: 13 reference(s)