Mir451a^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Mir451a^tm1Eno
• Name: microRNA 451a; targeted mutation 1, Eric N Olson
• MGI ID: MGI:4829385
• Gene: Mir451a Location: Chr11:77963996-77964067 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Mir451a^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163251
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT flanked neo resistance cassette was inserted 3' to Mir451 and a loxP site were placed flanking Mir451 and the reistance cassette. Northern blot analysis of bone marrow showed the absence of the Mir451 RNA. (J:163251)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir451a Mutation: 4 strains or lines available

References

• Original: J:163251 Patrick DM, et al., Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 2010 Aug 1;24(15):1614-9
• All: 1 reference(s)