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Jag2tm2.2Grid
Targeted Allele Detail
Summary
Symbol: Jag2tm2.2Grid
Name: jagged 2; targeted mutation 2.2, Tom Gridley
MGI ID: MGI:4829505
Synonyms: Jag2del2
Gene: Jag2  Location: Chr12:112871439-112893396 bp, - strand  Genetic Position: Chr12, 61.37 cM
Alliance: Jag2tm2.2Grid page
Cleft palate, fused tongue, and syndactyly in Jag2tm2.2Grid/Jag2tm2.2Grid fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163652
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT flanked PGKneo cassette and a distal loxP site were inserted into intron 2 and a second loxP site was inserted about 1.1 kb upstream of the start site via homologous recombination. Cre mediated recombination removed exons 1 and 2. In situ hybridization analysis indicated absence of RNA expression in E10.5 homozygous embryos. RT-PCR analysis detected low levels of expression in homozygous mice. (J:163652)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag2 Mutation:  44 strains or lines available
References
Original:  J:163652 Xu J, et al., Generation of mice with a conditional null allele of the Jagged2 gene. Genesis. 2010 Jun;48(6):390-3
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory