Jak2^tm1.1Jlvl
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1.1Jlvl
• Name: Janus kinase 2; targeted mutation 1.1, Jean-Luc Villeval
• MGI ID: MGI:4829538
• Synonyms: Jak2^V617F
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1.1Jlvl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 13 was replaced with one in which a G to T mutation results in an amino acid substitution of phenylalanine for valine at position 617 (V617F). An FRT flanked neo cassette downstream of the modified exon was removed by flp mediated recombination. (J:163497)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:163497 Marty C, et al., Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood. 2010 Aug 5;116(5):783-7
• All: 4 reference(s)