Cd300lb^tm1Toki
Targeted Allele Detail

Summary

• Symbol: Cd300lb^tm1Toki
• Name: CD300 molecule like family member B; targeted mutation 1, Toshio Kitamura
• MGI ID: MGI:4829592
• Synonyms: LMIR5^-
• Gene: Cd300lb Location: Chr11:114813605-114825197 bp, - strand Genetic Position: Chr11, 80.55 cM
• Alliance: Cd300lb^tm1Toki page

Cd300lb^tm1Toki/Cd300lb^tm1Toki mice were protected from renal ischemia reperfusion injury

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163402
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A construct containing a lacZ cassette and an FRT flanked neo cassette that was flanked with a mutant lox71 site and a loxP site replaced part of exon 1 and intron 1 beginning at the initiation site. Flow cytometry analysis confirmed the absence of expression in bone marrow cells from homozygous mice. (J:163402)

Generation of the Cd300lb^tm1Toki allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd300lb Mutation: 24 strains or lines available

References

• Original: J:163402 Yamanishi Y, et al., TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 2010 Jul 5;207(7):1501-11
• All: 5 reference(s)