Gon4l^justy
Chemically induced Allele Detail

Summary

• Symbol: Gon4l^justy
• Name: gon-4 like; justy
• MGI ID: MGI:4829629
• Gene: Gon4l Location: Chr3:88742531-88817406 bp, + strand Genetic Position: Chr3, 39.0 cM
• Alliance: Gon4l^justy page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion producing a cryptic splice site in intron 24 that results in the production of an expanded transcript. This modified transcript contains 81 additional nucleotides, including two premature stop codons. The absence of protein expression was confirmed by western blot analysis on cell lysates. (J:163412)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gon4l Mutation: 83 strains or lines available

References

• Original: J:163412 Lu P, et al., The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med. 2010 Jul 5;207(7):1359-67
• All: 3 reference(s)