Myh9^{tm4(GFP/MYH10/MYH9)Rsad}
Targeted Allele Detail

Summary

• Symbol: Myh9^{tm4(GFP/MYH10/MYH9)Rsad}
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 4, Robert S Adelstein
• MGI ID: MGI:4829691
• Synonyms: A^ba
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^{tm4(GFP/MYH10/MYH9)Rsad} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163702
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct encoding GFP fused to a chimeric gene coding for the amino acids 1 - 843 of human MYH10 and amino acids 837 - 1961 of human MYH9, a poly A signal, and a floxed neo resistance cassette was inserted into exon 2 after the ATG initiation codon. (J:163702)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 219 strains or lines available

References

• Original: J:163702 Wang A, et al., Nonmuscle myosin II isoform and domain specificity during early mouse development. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50
• All: 1 reference(s)